A synthesis of (+)-milbemycin β3. The directed aldol approach
- 1 January 1985
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1386-1388
- https://doi.org/10.1039/c39850001386
Abstract
A synthesis of (+)-milbemycin β, is reported in which key steps are the construction of the 1,7-dioxaspiro[5.5]undecane (15) by a Lewis acid-catalysed intramolecular directed aldol reaction and the use of sulphone-based olefination reactions for the construction of the double bonds at C(10)–C(11) and C(14)–C(15).Keywords
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