STUDIES ON EXPERIMENTAL HYPERTENSION

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Abstract
By means of a Ag chain attached to a Ag ring around the main renal artery, intermittent renal arterial occlusion, up to 30 mins. daily, was practiced for as long as 5 mos. in unilaterally nephrectomized dogs. This did not result in the development of persistently elevated blood pressure. Persistent moderate constriction of the renal artery of such animals by a Ag clamp, after intermittent temporary occlusion had failed to affect the blood pressure, produced the usual rise of blood pressure, without accompanying significant impairment of renal excretory function. When the renal artery accidentally became persistently constricted to a great degree, or actually occluded, or if occlusion was deliberately produced by continuous pulling of the chain, hypertension and renal insufficiency (the malignant phase) quickly developed. The results do not lend support to the view that brief daily periods of renal ischemia from intrarenal vaso-spasm, or from any other cause, can produce persistent hypertension of renal origin.

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