Effect of Neonatal or Later Capsaicin Treatment on Bronchial Reactivity in Sensitized Rats
- 1 January 1989
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 88 (1-2) , 234-236
- https://doi.org/10.1159/000234795
Abstract
Treatment of ovalbumin-sensitized rats with capsaicin resulted in altered bronchial reactivity to both ovalbumin and serotonin. The increase in bronchial reactivity to ovalbumin in neonatally capsaicin-treated rats compared to animals only sensitized may be influenced by the changed ratios of IgA, IgE, and IgG antibodies, together with the inflammation in the lung. Thus, capsaicin given neonatally inhibited the formation of antibodies, both specific titers and total levels, in bronchial lavage.Keywords
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