The effect of phallotoxins on the structure of F‐actin in myosin‐free ghost muscle fibres of rabbit
- 29 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 176 (2) , 441-443
- https://doi.org/10.1016/0014-5793(84)81214-4
Abstract
Using polarized UV fluorescent microscopy it has been shown that phallotoxins (phalloidin-sulfone, phalloidin-sulfoxide-B, phalloidin-sulfoxide-A and dithio-phalloidin) cause an increase in tryptophan fluorescence anisotropy of F-actin myofilaments in myosin-free ghost muscle fibres of rabbit. The results obtained are considered to be evidence of conformational changes in F-actin, induced by phallotoxins. These changes are irreversible to a significant extent, which points to a high degree of actin binding to both toxic and nontoxic phallotoxins.Keywords
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