THE PRODUCTION OF AN ACUTE RESPIRATORY DISEASE IN MONKEYS BY INOCULATION WITH BACILLUS INFLUENZAE

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Abstract
Many attempts have been made to produce influenza in animals, or to transmit it experimentally from man to man by inoculation of the secretions, both filtered and unfiltered, from the respiratory tract in cases of influenza, by direct exposure of the subject to patients with influenza, and by inoculation with cultures ofBacillus influenzaeisolated from patients with the disease. In large part, the results obtained have been entirely negative. In the few instances in which successful transmission of the disease has been reported, the methods employed and results obtained by different observers have been to a considerable extent inconsistent. During the course of an investigation of experimental pneumonia in monkeys produced by the intratracheal injection of pneumococcus andStreptococcus hemolyticus, a further series of experiments withB. influenzaewas undertaken in the hope of throwing some light on the relation which this organism bears to epidemic influenza and to

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