The Influence of Antibiotics on the Periodontal Syndrome in the Rice Rat

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Abstract
Three hundred and sixty-two rice rats were used in the study of the influence of antibiotics on the prevention and treatment of the periodontal syndrome. A benzylpenicillin preparation and erythromycin glucoheptonate were highly effective in the prevention of the syndrome, even at levels as low as 0.005% in the diet. Polymyxin B sulfate was effective at high levels but ineffective at comparably low levels. In curative trials, a benzylpenicillin preparation resulted in a regression of the soft-tissue lesions but was able only to retard the further progress in alveolar bone resorption. Oxytetracycline hydrochloride and a combination of a benzylpenicillin preparation and streptomycin sulfate were less effective than a benzylpenicillin preparation alone in the curative trials.

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