Granulocytopoiesis in Germfree Mice.

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Abstract
A comparison of the total number of neutrophils within the humerus of germfree and conventional mice revealed no significant difference between the 2 groups. The distribution of marrow neutrophils with respect to morphologic type and the number of neutrophils in mitosis were similar in the 2 groups. There was a slight, but significant, decrease in the concentration of blood neutrophils in germf ree mice as compared to controls. Removal of mice from the germfree environment was associated with a rapid decrease in the number of mature and relatively mature neutrophils in marrow and with subsequent increase in potentially mitotic, immature, neutrophils. Germfree mice responded to Salmonella endotoxin administration with an increase in the rate of release of neutrophils from the marrow, as do normal mice. In this model system, the presence or absence of microorganisms in the environment played little role in regulating granulocytopoiesis.

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