The inhibitory effect of 2:4-dinitrophenol on metastatic tissue calcification induced by calciferol

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Abstract
2:4-Dinitrophenol has been found to exert an inhibitory effect on soft-tissue calcification induced by calciferol. It did not affect the increases in blood calcium and in-organic phosphate induced by calciferol and appears to act directly on the tissues. It is suggested that the above effect of 2:4-dinitrophenol on calcification may be in part at least due to its known effects on adenosine triphosphate synthesis and adenosine-triphosphatase activity.