Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 88 (1) , 129-130
- https://doi.org/10.1007/bf00310528
Abstract
Serum corticosterone levels were determined following administration of the cholinergic agonist arecoline (4 mg/kg) to rats selectively bred for differences in cholinergic function. The Flinders Sensitive Line (FSL) of rats exhibited both greater suppression of behavioural activity and enhanced elevation fo serum corticosterone than the Flinders Resistant Line of rats. These enhanced responses to arecoline in the FSL rats parallel those reported in depressed humans, suggesting that these rats may provide a new animal model of affective disorders.This publication has 4 references indexed in Scilit:
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- Muscarinic supersensitivity of anterior pituitary ACTH and B-endorphin release in major depressive illnessPeptides, 1983
- Selective breeding for diisopropyl fluorophosphate-sensitivity: Behavioural effects of cholinergic agonists and antagonistsPsychopharmacology, 1982
- Increased vulnerability to cholinergic stimulation in affective-disorder patients [proceedings].1980