Interaction of SM-3997 with serotonin receptors in rat brain.
Open Access
- 1 January 1988
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 46 (3) , 311-314
- https://doi.org/10.1254/jjp.46.311
Abstract
The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT1A receptors but not the BZ-GABA receptor complex.Keywords
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