Conserved amino acid markers from past influenza pandemic strains
Open Access
- 1 January 2009
- journal article
- Published by Springer Nature in BMC Microbiology
- Vol. 9 (1) , 77
- https://doi.org/10.1186/1471-2180-9-77
Abstract
Finding the amino acid mutations that affect the severity of influenza infections remains an open and challenging problem. Of special interest is better understanding how current circulating influenza strains could evolve into a new pandemic strain. Influenza proteomes from distinct viral phenotype classes were searched for class specific amino acid mutations conserved in past pandemics, using reverse engineered linear classifiers.Keywords
This publication has 25 references indexed in Scilit:
- The Influenza Virus Resource at the National Center for Biotechnology InformationJournal of Virology, 2008
- The Origins of Pandemic Influenza — Lessons from the 1918 VirusNew England Journal of Medicine, 2005
- Characterization of the 1918 influenza virus polymerase genesNature, 2005
- Molecular characterization of the complete genome of human influenza H5N1 virus isolates from ThailandJournal of General Virology, 2005
- Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern AsiaNature, 2004
- MUSCLE: multiple sequence alignment with high accuracy and high throughputNucleic Acids Research, 2004
- Human Health Implications of Avian Influenza Viruses and ParamyxovirusesEuropean Journal of Clinical Microbiology & Infectious Diseases, 2004
- Support vector machines with selective kernel scaling for protein classification and identification of key amino acid positionsBioinformatics, 2002
- Characterization of the Influenza A Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1?Journal of Virology, 2000
- Case‐Control Study of Risk Factors for Avian Influenza A (H5N1) Disease, Hong Kong, 1997The Journal of Infectious Diseases, 1999