OBSERVATIONS ON THE BIOTIN REQUIREMENT OF THERMOPHILIC BACTERIA

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Abstract
The biotin requirements of 6 strains of Bacillus coagulans and 12 strains of B. stearothermophilus were studied. All biotin-requiring strains could utilize oxybiotin to satisfy this requirement. All strains utilized desthiobiotin although one strain of B. coagulans did so only at 36[degree]C and not at 45[degree] or 55[degree] C. Some strains satisfied their biotin requirement with aspartic acid. None of the tricarboxylic acid cycle intermediates satisfied the biotin requirement of any of the cultures at any incubation temp. employed. The relationship of these findings to the biosynthesis of biotin is discussed.
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