Evidence For Direct Utilization of Fructose in Working Muscle in Man.

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Abstract
Observations were made upon the effect of infused fructose of work capacity of a young male subject with an unusual metabolic deficiency of striated muscle in which there was a failure to form lactic acid under anaerobic conditions. The defect was tentatively ascribed to inability to utilize glycogen and was manifested clinically by limited exercise tolerance. Duration of work was greatly improved by infusion of glucose or fructose. Fructose was effective at much lower plasma concentration than glucose. Therefore, fructose can traverse the muscle cell membrane and contribute significantly toward the fuel for muscular work in this patient.

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