GRAVES-DISEASE - INSITU LOCALIZATION OF LYMPHOID T-CELL SUBPOPULATIONS
- 1 January 1983
- journal article
- research article
- Vol. 52 (2) , 311-316
Abstract
An in situ analysis of immunological features in thyroids from 15 Graves'' disease patients was performed. This study included a search for immune complexes visualized near the follicle''s basement membranes with fluorescent rabbit antisera to human IgG, IgA, IgM, C1q [complement component 1q], C3 and C9. Cellular immunity was investigated on the humoral side by visualization of B cells and plasma cells. Two series of monoclonal antibodies (OKT3, 4 and 8, Leu 1, 2a and 3a) were used to label the infiltrating cells'' membrane. These studies demonstrated the prevalence of T cells, a majority of them with OKT8/Leu 2a suppressor/cytotoxic phenotype. No correlation was found between this observation and peripheral blood T cell subsets analysis.This publication has 17 references indexed in Scilit:
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