Human antibody response to group A streptococcal teichoic acid

Publisher Website
Google Scholar
Abstract
The immunochemical characteristics and antibody levels in human sera to a specific group A streptococcal teichoic acid (TA) were studied. This phenol-extracted TA had DL-α-glycerophosphate as the major antigen determinant and not N-acetylglucosamine (N-AGA) as measured by an indirect hemagglutination assay (IHA). The group A streptococcal carbohydrate (A-CHO), N-AGA, and staphylococcal TA did not inhibit the streptococcal TA reaction. In studies of patients with or without history of acute rheumatic fever (ARF) or rheumatic heart disease (RHD), there was an inverse relationship between magnitude of TA hemagglutinating and A-CHO precipitating antibody (Ab) titers. Age-specific distribution of TA-Ab titers was not characteristic of titers observed against other streptococcal protein or carbohydrate antigens.

This publication has 0 references indexed in Scilit: