Eat Me or Die
- 28 November 2003
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 302 (5650) , 1516-1517
- https://doi.org/10.1126/science.1092533
Abstract
During embryonic development, the sculpting of many tissues depends on waves of apoptotic cell death among different cell populations. Unfortunately, at least in higher animals with sophisticated immune systems, dying cells must be engulfed by phagocytes to prevent a massive autoimmune response. In their Perspective, [ Savill et al .][1] discuss new work ([ Li et al .][2], [ Wang et al .][3]) that identifies a key receptor expressed by macrophages, PSR, that is essential for cell corpse engulfment. [1]: http://www.sciencemag.org/cgi/content/full/302/5650/1516 [2]: http://www.sciencemag.org/cgi/content/short/302/5650/1560 [3]: http://www.sciencemag.org/cgi/content/short/302/5650/1563Keywords
This publication has 10 references indexed in Scilit:
- Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12Science, 2003
- Phosphatidylserine Receptor Is Required for Clearance of Apoptotic CellsScience, 2003
- Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction SignalCell, 2003
- A blast from the past: clearance of apoptotic cells regulates immune responsesNature Reviews Immunology, 2002
- Phagocyte receptors for apoptotic cells: recognition, uptake, and consequencesJournal of Clinical Investigation, 2001
- Apoptosis: Corralling the CorpsesPublished by Elsevier ,2001
- JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2βTrends in Biochemical Sciences, 2001
- A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in VivoThe Journal of Experimental Medicine, 2000
- A receptor for phosphatidylserine-specific clearance of apoptotic cellsNature, 2000
- Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander LeukocytesThe Journal of Immunology, 1999