Body Temperature Response to Cocaine and Diazepam in Morphine-Treated Rats
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 25 (6) , 308-319
- https://doi.org/10.1159/000137757
Abstract
Since cocaine or diazepam are used clinically and/or abused concomitantly with narcotics, this study was designed to determine if morphine-dependent, morphine-withdrawn, or acute morphine rats exhibit an altered core body temperature at 24 or 4 °C to either cocaine (10, 20, or 30 mg/kg i.p.) or diazepam (2 or 4 mg/kg i.p.). At 24 °C, each dose of cocaine manifested hyperthermia in all groups of rats except morphine-dependent whereas at 4 °C cocaine produced hypothermia in all groups except morphine-dependent. At both 24 and 4°C, diazepam, 2 or 4 mg/kg, caused a hypothermic response in control, dependent, and withdrawn animals. At 24 °C, administration of acute morphine alone induced a hyperthermia which was antagonized by both doses of diazepam. At 4°C, acute morphine alone induced an initial hypothermia followed by a hyperthermia; both doses of diazepam potentiated the hypothermic response to acute morphine. Thus, significant alterations in core body temperature may be induced following the administration of cocaine or diazepam to morphine-treated rats.This publication has 9 references indexed in Scilit:
- Interactions of Δ9-tetrahydrocannabinol with d-Amphetamine, cocaine, and nicotine in ratsPublished by Elsevier ,2002
- Effect on core temperature of restraint after peripherally and centrally injected morphine in the Sprague-Dawley ratPharmacology Biochemistry and Behavior, 1979
- Potentiation of hexobarbital and amphetamine effects in male and female rats physically dependent on morphinePsychopharmacology, 1978
- Brain and plasma concentrations of morphine during the development of physical dependence and toleranceJournal of Pharmacy and Pharmacology, 1976
- Some effects of morphine on pituitary-adreno-cortical function in the ratBiochemical Pharmacology, 1967
- Diazepam metabolites in the rat: Characterization by high-resolution mass spectrometry and nuclear magnetic resonanceArchives of Biochemistry and Biophysics, 1967
- TEMPERATURE RESPONSES IN RAT FOLLOWING INTRACEREBRAL MICROINJECTION OF MORPHINE1965
- ADMINISTRATION OF PELLETS OF MORPHINE TO MICE - ABSTINENCE SYNDROME1961
- STUDIES ON THE MECHANISM OF STIMULATION OF ACTH SECRETION WITH THE AID OF MORPHINE AS A BLOCKING AGENT1Endocrinology, 1955