Synthesis of a 125I-labelled derivative of the antibiotic griseofulvin.
- 1 January 1977
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (11) , 965-968
- https://doi.org/10.7164/antibiotics.30.965
Abstract
A derivative of griseofulvin has been synthesised, in which the 2'-O-methyl group is replaced by a 2'-(2-iodoethoxy), 125I-labelled group. This derivative is at least as potent as griseofulvin itself, when assayed for inhibition of growth on the Myxomycete Physarum polycephalum.Keywords
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