An Improvement of the Anderson Test by the Use of High Performance Liquid Chromatography
- 1 February 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 61 (2) , 606-608
- https://doi.org/10.1246/bcsj.61.606
Abstract
The replacement of the N-benzyloxycarbonyl (Z) group in the Anderson peptide (Z–Gly–L/D–Phe–Gly–OEt) by Z–L-Ala and the subsequent separation of the diastereomers of the resulting tetrapeptide by reversed-phase HPLC offer a more convenient version with higher accuracy to the original Anderson test for studying racemization in peptide synthesis.Keywords
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