Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.
- 1 August 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (8) , 4033-4036
- https://doi.org/10.1073/pnas.75.8.4033
Abstract
Mutagenesis of mouse hepatitis virus with 5-azacytidine or 5-fluorouracil yielded several temperature-sensitive mutants. Mutants were isolated that dramatically enhance the production of demyelinating disease [in rats] over that previously noted with the wild-type virus. This reproducible model should now make possible the precise elucidation of the pathogenic mechanism and molecular basis of this virus-induced demyelination.Keywords
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