Adrenoceptive receptors in the duodenum, aorta and atria of the rabbit

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Abstract
PA10 values for the α-receptor blocking drug phentolamine against adrenaline, noradrenaline and phenylephrine were determined in rabbit aorta and duodenum, and for the β-receptor blocking drug propranolol, against adrenaline, noradrenaline and isoprenaline in rabbit atria and duodenum. The values for phentolamine against different amines were found to be similar, varying by less than half a log unit, between or within the tissues, as were the values for propranolol. These data provide quantitative evidence that α-receptors in the aorta and duodenum are similar, as are the β-receptors in the atria and duodenum, even though both types of receptor serve divergent functions in different tissues.

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