Increased Frequency of Circulating CCR5+CD4+T Cells in Human Immunodeficiency Virus Type 2 Infection
Open Access
- 15 December 2006
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 80 (24) , 12425-12429
- https://doi.org/10.1128/jvi.01557-06
Abstract
CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.Keywords
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