MOUSE FACTOR-B OF ALTERNATIVE PATHWAY OF COMPLEMENT ACTIVATION .1. PURIFICATION, CHARACTERIZATION, AND FUNCTIONAL BEHAVIOR

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (5) , 1799-1804
Abstract
Mouse factor B was purified and a monospecific antiserum was raised. The physicochemical data of this protein (108,000 MW, 5.9 S, 5.9-6.05 isoelectric point) were determined. The functional behavior resembles that of human and guinea pig factor B and it operates efficiently in the C3 feedback cycle of the alternative pathway of complement activation. A provisional scheme is given for the operation of the C3b.hivin.B enzyme on the cellular (macrophage) level.