Growth hormone and prolactin in tissue culture of pituitary adenoma.

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Abstract
Pituitary adenomas obtained from 6 patients with acromegaly and 8 patients with chromophobe adenoma were subjected to tissue culture to correlate in vitro secretion of growth hormone (GH) and prolactin (PRL) to preoperative in vivo endocrine studies and endocrinilogical manifestations. All acromegalic tumors secreted large amounts of GH for 2-4 wk, and some of the PRL secreting chromophobe adenomas without any clinical and endocrinological evidences of GH secretion secreted considerable amounts of GH. No recognizable GH secretion was noted in the remaining chromophobe adenomas. PRL was secreted in vitro in large amounts by tumors obtained from patients with hyperprolactinemia with and without acromegaly. It is interesting to note that tumors obtained from 2 patients who showed very slight elevations of plasma PRL of < 40 ng/ml secreted large amounts of PRL in vitro. This finding suggests that PRL secreting adenoma could not be ruled out in patients with mild hyperprolactinemia. The duration of in vitro PRL release was longer than that of GH and its rate of decrease was slower than that of GH.

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