In Utero Sensitization With Influenza Virus In Man
- 1 August 1975
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 149 (4) , 881-883
- https://doi.org/10.3181/00379727-149-38918
Abstract
Following a community-wide epidemic of influenza A/England virus infection, 64 cord blood samples were evaluated for their fetal serum and lymphocyte responses to this virus. Cord sera were tested for HI antibody vs. A/England with and without 2-ME. A fourfold or greater reduction in titer was observed in four, indicating fetal IgM antibody responses. In addition, lymphocyte samples from three of 16 tested showed proliferative responses to influenza A suggesting fetal lymphocyte sensitization with influenza virus. These data suggest that, in some pregnancies, influenza virus is capable of transplacental sensitization of the fetus.Keywords
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