Inhibition of Glucagon Secretion in the Human Newborn by Simultaneous Administration of Glucose and Insulin
- 1 January 1974
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 6 (05) , 392-396
- https://doi.org/10.1055/s-0028-1093831
Abstract
Glucose (1 gm/kg body weight) was administered intraportally to newborn infants, either alone or with intraportal insulin (0.1 or 0.3 U/kg body weight). As shown earlier, glucose alone did not suppress portal plasma glucagon; in contrast glucose plus insulin (at both doses used) resulted in a significant decrease in portal plasma glucagon. These data support the concept that insulin plays an important role in the physiologic sensitiveness of the alpha cell to glucose.Keywords
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