Randomized Trial of Chemotherapy Versus Chemotherapy Plus Radiotherapy for Stage I-II Hodgkin's Disease
- 16 November 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 80 (18) , 1466-1473
- https://doi.org/10.1093/jnci/80.18.1466
Abstract
A total of 277 patients with untreated Hodgkin's disease, clinical stages I-II, were randomized to cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP) alone for 6 monthly cycles or to CVPP plus radiation therapy (RT), 3,000 rad, to involved areas (CVPP plus RT). One or more of the following factors were considered as unfavorable prognosis: age >45 years, more than two lymph node areas involved, or bulky disease. In the favorable group, disease-free survival (77% vs. 70%) or overall survival (92% vs. 91%) at 84 months for CVPP versus RT plus CVPP was similar. Patients with unfavorable prognosis treated with RT plus CVPP had longer disease-free survival (75% vs. 34%) (P ═.001) and overall survival (84% vs. 66%) than patients treated with CVPP alone. [J Natl Cancer Inst 1988;80:1466–1473]Keywords
This publication has 22 references indexed in Scilit:
- Hodgkin's disease in children. Results of therapy in a mixed group of 178 clinical and pathologically staged patients over 13 yearsCancer, 1984
- A randomised study of adjuvant chemotherapy after mantle radiotherapy in supradiaphragmatic Hodgkin's disease PS IA-IIB: A report from the Manchester lymphoma groupBritish Journal of Cancer, 1984
- Prognostic significance of mediastinal mass in adult Hodgkin's diseaseCancer, 1984
- Patterns of care study: Hodgkin's disease relapse rates and adequacy of portalsCancer, 1983
- An evaluation of long-term survival and treatment complications in children with Hodgkin's diseaseCancer, 1983
- Patterns of care outcome studies: Results of the national practice in Hodgkin's diseaseCancer, 1983
- THE MANAGEMENT OF STAGE-I-II HODGKINS-DISEASE WITH IRRADIATION ALONE OR COMBINED MODALITY THERAPY - THE STANFORD EXPERIENCE1982
- Male gonadal dysfunction in Hodgkin's disease. A prospective studyJAMA, 1981
- Five-year results of the E.O.R.T.C. randomized study of splenectomy and spleen irradiation in clinical stages I and II of Hodgkin's diseasePublished by Elsevier ,1981
- Combined chemotherapy cyclophosphamide, vinblastine, procarbazine and prednisone (CVPP) V.S. CVPP PLUS CCNU (CCVPP) in Hodgkin's diseaseCancer, 1979