The large‐scale immobilization of Penicillium chrysogenum: Batch and continuous operation in an air‐lift reactor
- 20 October 1990
- journal article
- research article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 36 (8) , 763-770
- https://doi.org/10.1002/bit.260360802
Abstract
A temperature‐sensitive cell division cycle mutant of Penicillium chrysogenum P2 has been immobilized on Celite and grown in a 250–320‐L working volume air‐lift fermenter. The ability to uncouple growth and penicillin synthesis by raising the temperature to 30 °C also overcame the problem of the free cell mass which appeared after 300 h operation with the parent organism. After 500 h operation, penicillin and ACV dimer were still being synthesized.This publication has 16 references indexed in Scilit:
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