The Clinical Pharmacology of Antineoplastic Agents

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Abstract
(First of Two Parts)THE emergence of oncology as a medical subspecialty has been closely allied to the development of effective antineoplastic chemotherapy. Basic research into tumor-cell biochemistry and the effects of various antitumor agents have contributed markedly to this effort, and in recent years clinical pharmacology has become increasingly important in dealing with problems of host toxicity, tumor sensitivity and resistance, and therapeutic scheduling. It is the purpose of this article to review recent advances in the pharmacology of this class of drugs, emphasizing the factors that are likely to influence the clinical effectiveness of antineoplastic therapy.MethotrexateSince . . .