Abnormal concentrations of prostaglandins in amniotic fluid during delayed labour in multigravid patients

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Abstract
Concentrations of prostaglandins E (PGE), F2.alpha. (PGF), 13,14-dihydro-15-keto prostaglandin F2.alpha. (PGFM), 6-keto F1.alpha. and thromboxane B2 were measured by specific radioimmunoassay in samples of amniotic fluid from 22 multigravid patients during labor. Normal labor in 10 patients was associated with a significant increase of PGE, PGF and PGFM, with close correlation to cervical dilatation (P < 0.05). In the 12 patients with clinically delayed labor, in the absence of cephalopelvic disproportion, there were significantly lower PGF (P < 0.002) and PGFM (P < 0.05) concentrations obtained, while no differences were observed in the other prostanoids measured. Administration of oxytocin to the latter group to enhance labor did not have any effect on the concentrations of prostaglandins obtained, in spite of an improvement in intrauterine pressures and accelerated progress of labor.

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