Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis
Open Access
- 1 May 2000
- journal article
- Published by American Society of Hematology in Blood
- Vol. 95 (9) , 2943-2946
- https://doi.org/10.1182/blood.v95.9.2943.009k17_2943_2946
Abstract
Interactions between the Wiskott-Aldrich (WAS) protein (WASp), small GTPases, and the cytoskeletal organizing complex Arp2/3 appear to be critical for the transduction of signals from the cell membrane to the actin cytoskeleton in hematopoietic cells. This study shows that Fcγ-receptor (FcγR)-mediated phagocytosis is impaired in WASp-deficient peripheral blood monocytes, and that in macrophages, formation of the actin cup and local recruitment of tyrosine phosphorylated proteins is markedly attenuated. Results also show that, in normal macrophages, WASp itself is actively recruited to the cup, suggesting that assembly of this specialized cytoskeletal structure is dependent on its expression.Keywords
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