Correlation between Hyperinsulinemia and Hyperphagia in Rats with Ventromedial Hypothalamic Lesions

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Abstract
Plasma levels of immunoreactive insulin (IRI) and glucose were determined in unrestrained rats equipped with chronically implanted venous catheters. Electrolytic lesions were then placed bilaterally in the ventromedial hypothalamic area. Food intake was restricted in order to prevent hyperphagia. A 60–280 % increase in the IRI level with a concomitant small increase in blood glucose was demonstrated on the second day post‐operatively. The animals were then given free access to food. The gain in body weight during the following 3 days of ad lib feeding and the post‐operative increase in the IRI level of each animal was positively correlated.