Synthesis of Protein Complexes of Bis-indole Alkaloids from Catharanthus roseus
- 1 January 1986
- journal article
- research article
- Published by CLOCKSS Archive in HETEROCYCLES
- Vol. 24 (5) , 1355-1360
- https://doi.org/10.3987/r-1986-05-1355
Abstract
Conjugation of vincristine (VCR) 1 and vinblastine (VBL) 2 to proteins through the C-10'' position of the "catharanthine moiety" is described. The procedure was applied to the production of immunogenic complexes of the drugs and bovine serum albumin (BSAl), and to the synthesis of an enzyme-linked tracer from VCR1 and alkaline phosphatase.Keywords
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- Radioimmunoassays for the vinca alkaloids, vinblastine and vincristineAnalytical Biochemistry, 1979
- Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetyl vinblastine amide (vindesine) sulfateJournal of Medicinal Chemistry, 1978