Nucleoprotein Structure of Immediate-Early Promoters Zp and Rp and of oriLyt of Latent Epstein-Barr Virus Genomes
Open Access
- 15 April 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (8) , 4113-4118
- https://doi.org/10.1128/jvi.76.8.4113-4118.2002
Abstract
Genomic footprints across Rp, Zp, and oriLyt of Epstein-Barr virus (EBV) have been conducted in a panel of latently infected B-cell lines. Close protein-base contacts were found about 360 nucleotides upstream of the Zp initiation site. Gel shifts and transient transfection assays indicated that an Sp1-NF1 locus may serve as a repressive transcriptional element against Zp induction from latent EBV genomes.Keywords
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