Effect of phenobarbitone on the pharmacokinetics and tissue levels of amiodarone in the rat
- 1 October 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (10) , 729-731
- https://doi.org/10.1111/j.2042-7158.1985.tb04953.x
Abstract
Phenobarbitone pretreatment has been shown to increase amiodarone total clearance and decrease amiodarone elimination half-life after a single intravenous amiodarone dose in the rat. Coadministration of phenobarbitone with amiodarone for 7 days resulted in decreased tissue amiodarone levels compared to controls. These results may have Implications for patients undergoing therapy with amiodarone and concomitant potent enzyme inducing drugs.Keywords
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