Spontaneous Whole Brain Slow Potential Changes during Recovery from Experimental Neurosurgery

Abstract
Prolonged, nonlocalized brain slow potential changes, frequently associated with cortical spreading depression, occur spontaneously during 5 days following brain implant surgery in rats. These potentials are accompanied by reductions in multiple nerve cell activity and reductions in behavioral motility. The method used in this study provides a tool for evaluating recovery from neurosurgical trauma or other brain injuries, and for testing procedures that facilitate or impede this process.