Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity.
- 1 January 1990
- journal article
- research article
- Published by Japan Society for Cell Biology in Cell Structure and Function
- Vol. 15 (5) , 295-299
- https://doi.org/10.1247/csf.15.295
Abstract
Infection of the human lymphocyte CEM cell line with the HIV-1 (human immunodeficiency virus type-1, LAV-1 strain) results in cell death. A fluoroquinolone antibiotic, ofloxacin, protected the infected cells from HIV-1-mediated cytolysis. Other fluoroquinolones, e.g. ciprofloxacin, norfloxacin, and enoxacin, also protected the infected cells from HIV-1-mediated cytolysis. The d-isomer of ofloxacin (DR-3354) was about 50-fold less effective than l-isomer (DR-3355). Almost none of the rescued cells had detectable HIV-antigens and they could be maintained for long periods in vitro without drugs.This publication has 18 references indexed in Scilit:
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