Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to Acyclic Enones
- 21 September 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (40) , 12784-12785
- https://doi.org/10.1021/ja046632t
Abstract
A highly enantioselective Cu-catalyzed addition of Grignard reagents to acyclic aliphatic enones is described. In the presence of 5 mol % of CuBr.SMe2 and 6 mol % of JosiPhos diphosphine aliphatic enones react with Grignard reagents to provide beta-substituted linear ketones with high yields, regio-, and enantioselectivities.Keywords
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