Bronchographic Crystalline-Inclusion Pneumonia Due to Hytrast

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Abstract
Hytrast showed to incite an acute inflammatory response. With bronchography the crystals were retained in the bronchi and alveoli, causing a crystalline-inclusion pneumonia, a clinical entity complicating bronchography particularly with water-suspended contrast media, largely because of the peripheral dissemination in the small bronchioles and alveoli beyond the anatomical protective mechanisms. Post-bronchographic peripheral dissemination is aided further by the physiological secretions resulting from local irritation by elements of the contrast agent. Hytrast bronchographic crystalline-inclusion pneumonia is a relatively acute process with crystals in the bronchi and alveoli best demonstrated in microscopic sections through the use of polarized light. The reaction seldom shows significant gross or microscopic changes after five to seven days. The residua following an oily contrast medium often last for extended periods and were demonstrated in microscopic sections in this work for over fifteen months.

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