The chemistry of pyrrolic compounds. XLVII. The synthesis of a possible biogenetic precursor of haem a and its relationship to the prosthetic group ofmyeloperoxidase and to cryptoporphyrin a
- 1 January 1981
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 34 (4) , 871-883
- https://doi.org/10.1071/ch9810871
Abstract
The synthesis of 18-demethyl-18-formylprotoporphyrin dimethyl ester is described and the role of this compound as an intermediate in the biosynthesis of haem a is considered. A possible relationship between a compound of this structure and the prosthetic group of myeloperoxidase is discussed. The cryptoporphyrin a fraction of ox heart extracts has been reexamined and shown to consist of a mixture of Spirographis porphyrin and its isomer which presumably arise from the in vitro oxidation of the vinyl groups in protoporphyrin.Keywords
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