Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.
- 17 September 1996
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 93 (19) , 10343-10347
- https://doi.org/10.1073/pnas.93.19.10343
Abstract
NF-kappa B/Rel transcription factors are central regulators of mammalian immunity and are also implicated in the induction of cecropins and other antibacterial peptides in insects. We identified the gene for Relish, a compound Drosophila protein that, like mammalian p105 and p100, contains both a Rel homology domain and an I kappa B-like domain. Relish is strongly induced in infected flies, and it can activate transcription from the Cecropin A1 promoter. A Relish transcript is also detected in early embryos, suggesting that it acts in both immunity and embryogenesis. The presence of a compound Rel protein in Drosophila indicates that similar proteins were likely present in primordial immune systems and may serve unique signaling functions.Keywords
This publication has 33 references indexed in Scilit:
- Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attacin-like proteinsInsect Biochemistry and Molecular Biology, 1995
- Structure, Regulation and Function of NF-kappaBAnnual Review of Cell Biology, 1994
- Function and Activation of NF-kappaB in the Immune SystemAnnual Review of Immunology, 1994
- The inducible antibacterial peptides of insectsParasitology Today, 1994
- κB-like Motifs Regulate the Induction of Immune Genes in DrosophilaJournal of Molecular Biology, 1993
- Molecular Cloning and Characterization of a Novel Rel/NF-χB Family Member Displaying Structural and Functional Homology to NF-χB p50/p105DNA and Cell Biology, 1992
- B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50Cell, 1991
- Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targetingTrends in Genetics, 1991
- Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsalCell, 1990
- The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene productCell, 1990