ASSOCIATION OF HL-A-B8 AND CHILDHOOD CELIAC-DISEASE IN AN ISRAELI POPULATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 13  (4) , 400-404
Abstract
The frequency of human histocompatibility antigens (HLA) was studied in 33 children with celiac disease. HLA-B8 phenotype was detected in 27.3% of the celiac patients and 7.5% of 395 carefully matched control subjects (.chi.2 for heterogeneity = 14.23; P < 10-4). HLA typing, especially in children, is advocated both as a diagnostic and a prognostic measure. The importance of ethnically matched control subjects is discussed together with a proposal for the construction of such control groups.

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