Synthetic Studies of the Rutamycins. Construction of the C1-C15 Subunit of Rutamycin B
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (07) , 535-538
- https://doi.org/10.1055/s-1993-22520
Abstract
The linear, polypropionate portion of the macrolide antibiotic rutamycin B was synthesized by stereoselective, aldol condensation of a ketone and an aldehyde comprising C1-C8 and C9-C15 segments, respectively. Both subunits originated from (R)-3-hydroxy-2-methylpropionate, which was elaborated using crotylstannane and asymmetric crotylboronate methodology.Keywords
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