Influence of Inhibitors of Protein Synthesis on Zinc Metabolism
- 1 December 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 156 (3) , 505-508
- https://doi.org/10.3181/00379727-156-39967
Abstract
The drugs actinomycin D, chloramphenicol, cordycepin and cycloheximide were evaluated for their relative effectiveness in blocking Zn binding by rat liver and mucosa following parenteral Zn. All the drugs, except chloramphenicol, were effective. The majority of the additional Zn bound following parenteral Zn was accounted for as metallothionein (MT) Zn. The inhibition of Zn binding by the drugs used was restricted to that associated with MT. The results collectively indicate that Zn uptake in liver and intestinal cells involves nonmitochondrial transcription and translation of poly(A)-containing RNA. Some of this RNA appears to code for MT.This publication has 4 references indexed in Scilit:
- Control of zinc-thionein synthesis in rat liverBiochemical Journal, 1977
- Isolation of an intestinal metallothionein induced by parenteral zincBiochemical and Biophysical Research Communications, 1977
- Degradation of hepatic zinc-thionein after parenteral zinc administrationBiochemical Journal, 1976
- Metallothionein and its Relationship to the Metabolism of Dietary Zinc in RatsJournal of Nutrition, 1976