Further studies on a hybrid cell-surface antigen associated with human chromosome 11 using a monoclonal antibody

1 July 1983

journal article
research article
Published by Springer Nature in Somatic Cell and Molecular Genetics

Vol. 9 (4) , 489-496
https://doi.org/10.1007/bf01543049

Abstract

A monoclonal antibody has been obtained that recognizes an antigen encoded by human chromosome 11. We present evidence that this monoclonal antibody recognizes the same or a similar antigenic activity as that previously called a₁. Genetic information necessary for a₁ expression and recognition by the monoclonal antibody both map to 11p13 → 11pter. Mutants that have lost a₁ are no longer recognized by the monoclonal antibody. The macroglycolipid fraction of human erythrocyte membranes which contains the a₁ antigenic activity is able to convert antigen-negative Chinese hamster ovary cells into cells which are killed by the monoclonal antibody plus complement.

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