Preparation of 8-oxo-7-(1-hydroxyethyl)-3-oxa-1-azabicyclo[4.2.0]octane derivatives: intermediates for thienamycin synthesis
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 19,p. 846-847
- https://doi.org/10.1039/c39790000846
Abstract
Readily available tetrahydro-1,3-oxazines on acylation with diketen followed by diazo exchange, irradiation, and reduction give 8-oxo-7-(1-hydroxyethyl)-3-oxa-l-azabicyclo[4.2.0]octane derivatives having trans-substituents about the β-lactam ring.Keywords
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