Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease
- 1 August 1998
- journal article
- Published by Springer Nature in Nature Medicine
- Vol. 4 (8) , 963-966
- https://doi.org/10.1038/nm0898-963
Abstract
Substitutive therapy using fetal striatal grafts in animal models of Huntington disease (HD) have already demonstrated obvious beneficial effects on motor indices. Using a new phenotypic model of HD recently designed in primates, we demonstrate here complete and persistent recovery in a frontal-type cognitive task two to five months after intrastriatal allografting. The striatal allografts also reduce the occurrence of dystonia, a major abnormal movement associated with HD. These results show the capacity of fetal neurons to provide a renewed substrate for both cognitive and motor systems in the lesioned adult brain. They also support the use of neural transplantation as a potential therapy for HD.Keywords
This publication has 19 references indexed in Scilit:
- Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of PhencyclidineScience, 1997
- Chronic 3-Nitropropionic Acid Treatment in Baboons Replicates the Cognitive and Motor Deficits of Huntington’s DiseaseJournal of Neuroscience, 1996
- Ontogeny of Human Striatal DARPP-32 Neurons in Fetuses and Following Xenografting to the Adult Rat BrainExperimental Neurology, 1996
- Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's diseaseNeuroscience, 1995
- Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.Proceedings of the National Academy of Sciences, 1995
- Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington diseaseNeuroscience, 1995
- A primate model of Huntington's disease: Behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboonExperimental Neurology, 1990
- Differential cognitive impairment in alzheimer's disease and huntington's diseaseAnnals of Neurology, 1988
- Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survivalBrain Research, 1985
- Comparison of the Neuropsychological Deficits Associated With Early and Advanced Huntington's DiseaseArchives of Neurology, 1978