Granulomatous Prostatitis with Emphasis on the Eosinophilic Variety

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Abstract
Towfighi, Javad, Sadeghee, Saeed, Wheeler, James E., and Enterline, H. T.: Granulomatous prostatitis with emphasis on the eosinophilic variety. Am. J. Clin. Pathol. 58: 630–641, 1972. Twenty-eight cases of nonspecific granulomatous prostatitis are presented. Those cases showing an eosinophilic infiltrate are reported in detail and analyzed with ones found in a comprehensive review of the literature. Simple eosinophilic granulomatous prostatis is occasionally associated with an allergic history (20%); those cases containing the additional element of fibrinoid necrosis or vasculitis almost invariably have an allergic history (94%). Eosinophilic granulomatous prostatitis does not indicate a grave prognosis unless associated with diffuse vasculitis. A history of previous prostatic transurethral resection was present in 47% of our patients with nonspecific granulomatous prostatitis, all of whom had benign prostatic hypertrophy. The significance of this finding together with other factors in the pathogenesis of prostatic granulomas is discussed. The bladder was involved in two cases of eosinophilic granulomatous prostatis in our series. This association, so far as we are aware, has not been reported previously. A histologic classification of nonspecific granulomatous prostatitis is suggested.

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