Concentrations of Ceftriaxone in Serum and Lung Tissue

Abstract
19 patients received an intravenous 5-min bolus injection of 2 g ceftriaxone at various times before thoracic surgery. Lung tissue concentrations of 31.8 μg/g could be maintained for at least 5 h. Serum and lung tissue concentrations of ceftriaxone are high enough to inhibit most organisms causing nosocomial and community-acquired respiratory tract infections.

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