Effect of Histamine Receptor Blocking on Human Antibody-dependent Cell-mediated Cytotoxicity
- 1 April 1981
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 13 (4) , 361-366
- https://doi.org/10.1111/j.1365-3083.1981.tb00145.x
Abstract
The effect of H1 and H2 receptor-blocking agents on antibody-dependent cell-mediated cytotoxicity (ADCC) was studied. The H1 receptor blocker clemastinum and the H2 receptor blocker cimetidine dose-dependently inhibited the antibody-dependent cytotoxic activity of normal human peripheral blood mononuclear cells on chicken erythrocytes. The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors. The possible involvement of histamine receptor-bearing effector cells in human ADCC is suggested.This publication has 9 references indexed in Scilit:
- Histamine receptor-bearing T lymphocytes in patients with allergy, autoimmune disease, or recurrent infectionClinical Immunology and Immunopathology, 1978
- Lack of effector cell function in chronic lymphocytic leukemia, a B-cell malignancy, and the Sézary syndrome, a T-cell malignancyClinical Immunology and Immunopathology, 1978
- The separation and reactivity in vitro of a subpopulation of human lymphocytes which bind histamine. Correlation of histamine reactivity with cellular maturationCellular Immunology, 1976
- Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.Journal of Clinical Investigation, 1976
- Properties of a subpopulation of T cells bearing histamine receptors.Journal of Clinical Investigation, 1975
- Modulation of Inflammation and Immunity by Cyclic AMPScience, 1974
- Rosette formation by human T and B lymphocytesEuropean Journal of Immunology, 1973
- SURFACE MARKERS ON HUMAN T AND B LYMPHOCYTESThe Journal of Experimental Medicine, 1972
- Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytesCellular Immunology, 1970